SIRT1 and Alzheimer disease: This is because the lifestyle and brain metabolism-associated AMP-activated protein kinase (AMPK) and silent information regulator 1 (Sirt-1) signaling have a key role in maintaining cellular homeostasis and protecting the cells against external and internal stress or insults and have a protective role in AD pathologies (Shah et al., 2017; Gu et al., 2018; Yoon et al., 2018; Ali et al., 2021).