•Examination of SFPQ in AD's brain tissue showed down-regulation.•SFPQ in AD's brain showed nuclear depletion and cytoplasmic colocalization with TIA-1.•SFPQ showed extra-nuclear colocalization with p-Tau in AD's brain legions.•There is probably a link between SFPQ and Tau oligomers in oligomerization and misfolding. This evidence concerns the gene MAPT and Alzheimer disease.