MAPT and Alzheimer disease: The most common form of dementia is AD, which occurs with abnormal structures (Wang et al., 2018), extracellular senile plaques, composed mainly of small proteins called Aβ42 (Bate et al., 2006), and intraneuronal neurofibrillary tangles, which are the result of accumulations of hyperphosphorylated Tau proteins (Bancher et al., 1989).