Several studies have reported that Aβ aggregation affects the structural and functional properties of synaptic mitochondria and their synaptic transport in brain tissues of AD patients and amyloid precursor protein (APP) transgenic mice (Mungarro-Menchaca et al., 2002; Caspersen et al., 2005; Manczak et al., 2006, 2018; Pickett et al., 2018). The gene discussed is APP; the disease is Alzheimer disease.