• SOD1G93A and TDP43A315T mutations of ALS show enrichment in mitochondria related mRNAs; most genes altered in the SOD1 model were not altered in the TDP43 model; novel list of axonal miRNAs with altered expression levels. • Open the possibility that axon local translation could module initial stages of ALS and bring possible teraphies. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.