AD pathogenesis is complex, involving abnormal amyloid beta (Aβ) metabolism, tau hyperphosphorylation, oxidative stress, reactive glia and microglia changes, and other pathological events [please refer to Khan and Bloom (2016); Wang et al. (2017), Femminella et al. (2018), and Guo et al. (2020)]. Here, MAPT is linked to Alzheimer disease.