APP and Alzheimer disease: In the same line the group of Hengst visualized nascent locally synthesized proteins by BONCAT assay in hippocampal neuronal axons exposed to Aβ1–42 oligomers and found partial overlap with controls, dysregulation of mRNAs previously reported as AD-related genes including APP, ApoE, Clu, and FERMT2 and novel ones like ATF4 for which was demonstrated its role in neurodegeneration progression (Baleriola et al., 2014).