Mutations in SOD1, C9orf72, TARDBP, and FUS are known genes contributing toward ALS (Rosen, 1993; Kwiatkowski Jr., Bosco et al., 2009; Vance et al., 2009; DeJesus-Hernandez et al., 2011). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.