PPP1CB and amyotrophic lateral sclerosis: • Perform network analysis and identified Staufen1 as major mediator of dynein interactions trough PP1B protein. • Demonstrate that Dynein-Staufen-PP1B interactions was altered in ALS models. • Suggest a model in which dynein at synases do clustering and anchoring of mRNAs including Staufen and these interaction regulate mRNA localization along the axon and the synapses and is altereded in ALS models