Moreover, endothelial senescence and Alzheimer's disease (AD) were associated with ANG II-activated ADAM17, connecting both proteins to microvascular aging and disrupted biological barriers (Shatanawi et al., 2011; Morancho et al., 2015; Qian et al., 2016; Dou et al., 2017; Li et al., 2019; Shalaby et al., 2020). This evidence concerns the gene ADAM17 and Alzheimer disease.