In addition, as VEGF also regulates angiogenesis, endothelial senescence and efferocytosis, the disruption of NRP-1/IL-10/VEGF axis likely triggers the ME/CFS and COVID-19 pathogenesis (Watanabe et al., 1997; Hasan et al., 2011; Kearns et al., 2012). The gene discussed is VEGFA; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.