For example, extracellular HMGB1 (a molecule upregulated by ANG II) is a potent DAMP associated with COVID-19 cytokine storm and several autoimmune disorders (Friggeri et al., 2010; Banerjee et al., 2011; Harris et al., 2012; Magna and Pisetsky, 2014; Tsung et al., 2014; Chen R. et al., 2020; Mangalmurti and Hunter, 2020; Figure 1). This evidence concerns the gene AGT and COVID-19.