ACE2 and COVID-19: Indeed, overactive ADAM17 with excessive shedding of MerTK and ACE-2 could comprise a significant pathogenetic mechanism of COVID-19 and ME/CFS (Casciola-Rosen et al., 2020; Chaudhary, 2020; Megremis et al., 2020; Miesbach, 2020; Pagliaro and Penna, 2020).