Dysfunctional renin-angiotensin system (RAS) was previously associated with accelerated aging as excess ANG II induces telomere attrition as demonstrated in both severe COVID-19 illness and children with Hutchinson-Gilford progeria, a syndrome of accelerated aging (Regenass et al., 1994; Herbert et al., 2008; Gerhard-Herman et al., 2012; Amraei and Rahimi, 2020; Benetos et al., 2020; Bidault et al., 2020; Libby and Lüscher, 2020). This evidence concerns the gene AGT and Hutchinson-Gilford progeria syndrome.