Moreover, SARS-CoV-2/NRP-1 attachment and dysfunctional VEGF in IECs, myocytes, ECs and Tregs was associated with disabling fatigue, further connecting these proteins to ME/CFS (Yadav et al., 2012; Wang et al., 2015; Yamaji et al., 2015; Issitt et al., 2019; Cantuti-Castelvetri et al., 2020; Davies et al., 2020; Moutal et al., 2021; Table 1). The gene discussed is VEGFA; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.