AGT and myalgic encephalomeyelitis/chronic fatigue syndrome: ANG II also inhibits the muscle tissue repair, generating myopathy and atrophy as well as endothelial and immune damage, further implicating dysfunctional RAS in ME/CFS symptoms (Ferrario et al., 2005; Turowski et al., 2005; Cabello-Verrugio et al., 2012; Morris et al., 2014; Wyller et al., 2016; Cooper et al., 2018; Tirone et al., 2018; Monteil et al., 2020; Figure 1).