SOD1 and amyotrophic lateral sclerosis: Neurofilaments are currently highly discussed as a biomarker for ALS as levels of neurofilament light-chain are shown to be highly increased in the plasma of patients with ALS (Zetterberg et al., 2007) but also in SOD1-G93A/low mice at the age of 27 weeks (Loeffler et al., 2020).