MAPT and tauopathy: Under pathological conditions, such as in human tauopathy or animal models of tau overexpression, the presence of tau at synapses is more apparent, suggesting a role for tau in disease pathogenesis (Hoover et al., 2010; Ittner et al., 2010; Pooler et al., 2014; Sokolow et al., 2015; Dejanovic et al., 2018; Ji et al., 2019; Kubo et al., 2019).