Through KEGG pathway analysis, the top 10 enriched pathways found as below: neuroactive ligand-receptor interaction, insulin resistance, pathways of neurodegeneration-multiple diseases, vascular smooth muscle contraction, regulation of actin cytoskeleton, hippo signaling pathway, herpes simplex virus 1 infection, inflammatory mediator regulation of TRP channels, adipocytokine signaling pathway, and proteoglycans in cancer (Figure 5B). Here, INS is linked to cancer.