Furthermore, previous studies have shown that certain classes of antihypertensive medications (e.g., angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers) are associated with lower PTSD symptoms in trauma-exposed individuals (Khoury et al., 2012; Seligowski et al., 2021), and that the effects of these antihypertensive medications may be dependent on genetic liability (Nylocks et al., 2015). This evidence concerns the gene ACE and post-traumatic stress disorder.