TGFB1 and neoplasm: For instance, low dose of LXA4 could inhibit the proliferation and metastasis in OVC cells, Hela cells, as well as in papilloma.350,408,409 Besides, RvD1 and RvD2 were shown to prevent metastasis of A549 by reducing EMT induced by TGF-β1.410 Likewise, RvD1 was reported to induce caspase-3, thus increasing the apoptosis of pancreatic ductal adenocarcinoma cells in vitro.411 Furthermore, SPM are also known to display anti-tumor actions by targeting immune cells.