PRF1 and neoplasm: Briefly, γδ-T cells recognize and directly kill tumor cells through TCR and natural killer cell receptors (NKR).404 The tumor cell killing of γδ-T cells was shown to be mediated by the TRAIL associated with TNF, Fas-L, or granulosa cell pathway (leading to the secretion of perforin and granzyme).405 Moreover, γδ-T cells could also destroy tumor cells through ADCC after treatment with tumor-specific antibodies.406