Eosinophils were demonstrated to promote tumor metastasis and angiogenesis via the secretion of MMP9, VEGF, FGF, and PDGF, while polarize TAMs into a pro-tumor (M2) phenotype via the production of IL-4 and IL-13.347 Thus, the function of eosinophils might depend on the cellular composition of the TME in different cancer types. This evidence concerns the gene MMP9 and neoplasm.