Evidence has shown that PGE2 shifts the balance away from Th1 responses toward Th2 responses.851 Overproduction of PGE2 has been observed in multiple Th2-associated diseases, including atopic dermatitis and asthma.852 Moreover, inhibition of prostaglandin synthesis using COX2 inhibitors was reported to cause an augmentation of the Th1 response,853 suggesting that reducing the production of PGE2 would induce the Th1 response, improving the efficacy of anti-tumor immunotherapy. Here, PTGS2 is linked to neoplasm.