For example, activation of type 1 IFN response, such as recombinant IFN, CpG oligodeoxynucleotide, and 3′3′-Cgamp, can boost anti-cancer efficacy in synergy with immunotherapies.457 Besides, radiotherapy can trigger acute local inflammation, which sensitizing tumor cells to ICB therapy.458. This evidence concerns the gene IFNA1 and neoplasm.