The prognostic significance of TIBs was basically reported to be consistent with that of CD3+ and CD8+ T cells, with the anti-tumor activity of T cells being generally shown to be more potent in the presence of TIB cells.428 Finally, accumulating evidence have supported a positive role for TIB in anti-tumor immunity,427,429,430 suggesting that enhancement of these responses should be considered in future cancer immunotherapies. This evidence concerns the gene CD8A and cancer.