Excessive activation of NLRP3 or gene mutations have been reported to cause severe inflammatory diseases, such as familial cold-induced autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal onset multisystem inflammatory disorder or chronic infantile neurologic cutaneous and articular syndrome (NOMID/CINCA).228. This evidence concerns the gene NLRP3 and Muckle-Wells syndrome.