IFNG and infection: Almost all patients with COVID-19 are clinically presented with fever, cough, and dyspnea.207,208 Moreover, infection with SARS-CoV-2 has been associated with systemic inflammation, and increased serum levels of inflammatory cytokines and chemokines, including IL-1, IL-7, IL-8, IL-9, IL-10, GM-CSF, and IFN-γ, which have been associated with disease severity and death.209–211