Nevertheless, the TME also contain a network of immunosuppressive factors (e.g., IL-6, M-CSF, PGE2, and VEGF) that could inhibit the infiltration of DCs and subdue their anti-tumor activity.527 Therefore, targeting these immunosuppressive pathways might improve the recruitment, infiltration, and anti-tumor activity of DCs in the TME. This evidence concerns the gene VEGFA and neoplasm.