CD4 and cancer: Recently, universal cancer peptides (UCP), novel anti-tumor Th1-inducer peptides derived from hTERT, were demonstrated to induce a spontaneous CD4 T-cell response in 38% of patients with metastatic NSCLC, with the high-avidity UCP-specific CD4 T cells being Th1 polarized.846 In addition, tumor cell loaded type-1 polarized DCs induced the activation of antigen-specific Th1-type CD4+ T cells, resulting in a significant reduction in tumor growth.847