LXA4, an endogenous eicosanoid derived from AA, has been highlighted in the regulation of inflammation.886 Evidence have shown that LXA4 repressed the generation of Breg cells by dephosphorylating both STAT3 and ERK, resulting in impaired tumor growth.26 Targeting Breg cells by LXA4 decreased the number of Treg cells in tumor tissues, as well as enhanced the activities of cytotoxic T cells.26 These findings revealed that targeting Breg cells through the administration of LXA4 could have potential clinical applications. The gene discussed is STAT3; the disease is neoplasm.