CD8A and cancer: Administration of IL-2 during chronic viral infection was demonstrated to exhibit striking synergistic effects with PD-1 blockade, thus enhancing virus-specific CD8+ T cells.787 The synergy of exogenous IL-2, PD-1 blockade, and a powerful T-cell vaccine combination therapy has been confirmed in a cancer model.788 Besides, blockade of IL-10R significantly improved the efficacy of anti-PD-L1 treatment, resulting in enhancing the function and viral clearance of T cells.789