HMGB1 and juvenile idiopathic arthritis: Nonetheless, data from all collected samples of patients with JIA revealed that serum HMGB1 levels were significantly associated with ESR (P = 0.0102), CRP (P < 0.0001), percentage of neutrophils (P = 0.0079), JADAS-27 (P < 0.0001), sJADAS-27 (P < 0.0001), and JSpADA (P = 0.0164), as illustrated in Fig. 3.