To meet the need to respond appropriately to different kinds of DNA damage, mammalian cells have evolved intricate DNA repair pathways to repair a large variety of structurally genotoxic damages: mismatch repair (MMR), base-excision repair (BER), nucleotide excision repair (NER), homologous recombination (HR), non-homologous DNA end joining (NHEJ) pathway, translesion synthesis (TLS), Fanconi anemia (FA) and checkpoint factors (CPF). Here, FANCA is linked to Fanconi anemia.