A number of studies have now implicated PDE5 inhibition in ischemic pre- and postconditioning, cardioprotection and ischemia-reperfusion injury,42 reducing infarct size, apoptosis, and postinfarct remodeling, and via a pathway involving opening of BK channels.43,44 Such effects are likely contributors in explaining reduced arrhythmias in these contexts. Here, PDE5A is linked to ischemia.