ACSS1 and hepatocellular carcinoma: Some meaningful subtypes as well as the metabolic, signaling, and immune characters were recognized,[12, 13, 14, 15] for example, ACSS1 was found to be related with HCC tumor growth and malignancy under hypoxia conditions based on a genome scale metabolic (GEM) model of HCC.[12] However, these analyses focused particularly on proteins or enzymes rather than metabolites or MPIs which also play key functions in cancers, limiting our understanding about metabolic pathways.