HIF1A and hepatocellular carcinoma: According to the mRNA profiles, most of the metabolism pathways were down‐regulated in the poor prognostic subtype C1 compared to C2, including the glycolysis pathway which was expected to be up‐regulated given the up‐regulation of HIF‐1 signaling and the hypoxia condition[22] in C1, and this observation was consistent across four HCC cohorts (Figure 4a).