ANGPT2 and neoplasm: Angiogenesis factors, including vascular endothelial growth factor (VEGF) and angiopoietin 2 (ANG2), contribute to immune suppression via repressing APCs and other antitumor immune effector cells, or via potentiating the function of immunosuppressive Tregs, myeloid-derived suppressor cells (MDSCs), and M2-tumor-associated macrophages (TAMs) [2].