In subcutaneous models of lung cancer and melanoma, ablative hypofractionated radiation therapy (23 Gy/2f) had greater efficacy than conventional fractionated radiation therapy (36 Gy/9f) in tumor growth inhibition and mouse survival improvement by reducing the accumulation of MDSCs into TME and decreasing their level of PD-L1 [75]. Here, CD274 is linked to lung cancer.