Certain proinflammatory factors, such as CXCL9, CXCL10, and CXCL16, promote the trafficking of immune cells into the tumor, increase leukocyte chemoattraction and extravasation, and induce tumor surface expression of PD-L1, MHC-I, NK cell ligand, and Fas (CD95) [10,41,57,]. This evidence concerns the gene CXCL9 and neoplasm.