In addition, in the tumour tissues derived from ALDH+CD44+CXCR4+CD24+-PCa cells implanted into the dorsal lobe of NOD/SCID mouse prostates for 6 weeks, we observed the presence of CXCR4– and (or) CD24– cells (Supplementary Fig. 1E), suggesting that ALDH+CD44+CXCR4+CD24+-PCa cells are pluripotent and can differentiate into multiple progenies in vivo. This evidence concerns the gene CD44 and neoplasm.