Hsu et al. [29] demonstrated that Jab1/CSN5 was upregulated in HCC and suppressed Jab1/CSN5 induced by peroxisome proliferator-activated receptor-gamma (PPARγ) ligands cause the induction of cell apoptosis and the inhibition of cell cycle progression, which impair the proliferation of HCC. Here, COPS5 is linked to hepatocellular carcinoma.