SNHG6 inhibited the expression of MAT1A protein, which was expressed in quiescent adult hepatocytes and upregulated the SAMe concentration in the liver [41], by the activation of the miR-1297/FUS (fused in sarcoma) pathway to modify the nucleocytoplasmic shuttling of MAT1A mRNA and promoted the expression of MAT2A by inhibiting the direct binding of miR-1297 to the MAT2A 3′UTR [42]. The gene discussed is MAT2A; the disease is sarcoma.