MAP2K1 and neoplasm: At days 36 and 39, tumor growth and metastasis were delayed in MEK1 inhibitor-treated animals (day 39; controls: mean lateral signal 3.4 × 106, CI 1.9 × 106–4.8 × 106, AZD6244: mean lateral signal 1.2 × 106, CI 0.69 × 106–1.7 × 106, p < 0.01, GSK1120212: mean lateral signal 1.6 × 106, CI 1.3 × 106–2.0 × 106, p < 0.01; controls: mean ventral signal 2.6 × 106, CI 1.7 × 106–3.5 × 106, AZD6244: mean ventral signal 1.4 × 106, CI 0.8 × 106–1.9 × 106, p < 0.05, GSK1120212: mean ventral signal 1.5 × 106, CI 0.97 × 106–2.1 × 106, p < 0.05, Fig. 1E–G).