METTL3 stabilizes the expression of HK2 and SLC2A1 (GLUT1) in CRC through a mechanism dependent on the m6A-IGF2BP2/3-METTL3/HK2/GLUT1-IGF2BPs axis, which plays a key role in CRC pathogenesis. Here, IGF2BP2 is linked to colorectal carcinoma.