Xia et al. also confirmed that, unlike the low METTL3 phenotype, the high METTL3 phenotype is significantly positively correlated with the poor prognosis of ESCC, and they proposed that METTL3 expression level is an independent predictor of disease-free survival (DFS) and overall survival (OS) in patients with ESCC [34]. Here, METTL3 is linked to esophageal squamous cell carcinoma.