Collectively, the above information showed that restraining UBXN1, LXRα and HIVEP2 expressions may have a synergistic effect in promoting tumorigenesis, and YTHDF2 overexpression could promote the tumorigenesis of glioma via accelerating the decay of LXRα, HIVEP2 and UBXN1 mRNA simultaneously. The gene discussed is NR1H3; the disease is central nervous system cancer.