Collectively, the above information showed that restraining UBXN1, LXRα and HIVEP2 expressions may have a synergistic effect in promoting tumorigenesis, and YTHDF2 overexpression could promote the tumorigenesis of glioma via accelerating the decay of LXRα, HIVEP2 and UBXN1 mRNA simultaneously. Here, YTHDF2 is linked to central nervous system cancer.