LMNA and cardiovascular disorder: Furthermore, despite shared DMRs having little to no association to TFBS motif pathways and disease ontologies related to laminopathies, a relatively larger number of DMR-associated genes related to cardiovascular disease were present in both Family A and C. Thus, the identification of these epimutation hotspots across samples from families with distinct LMNA mutation suggests that family-specific aberrances in DNA methylation might lead to common functional consequences in DCM.