NLRP3 and endothelial dysfunction: Plausible explanations for the possible benefits of statins seen in this patient population could include anti-inflammatory and immunomodulating properties of statins, including T cell signaling, modulation of cytokine production [16, 17], protection against vascular injury and endothelial dysfunction [13–15], inhibition of MYD88 gene and thereby activation of NF-kb pathway [41, 42], and pleiotropic effect on NLRP3 inflammasome activation and cytokine release [43, 44].