Beyond its well-known role in innate immunity, TBK1 has been implicated in oncogenesis and metabolic disorders linked to obesity such as type II diabetes, similar to mTOR and Akt (14, 15, 16, 17, 28, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54). Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.