TBK1 and obesity due to melanocortin 4 receptor deficiency: In mice with diet-induced obesity, adipocyte-specific knockout of TBK1 decreases Akt S473 phosphorylation in white adipose tissue, increases whole-body insulin resistance and proinflammation, and impairs glucose homeostasis (50, 54), a phenotype that overlaps with that resulting from adipocyte-specific knockout of Raptor (mTORC1) or Rictor (mTORC2) (28, 56, 57, 58).