In oncogenic KRas-transformed cells, TBK1 promotes cell proliferation and survival and the growth of tumor explants in vivo, with either mTORC1 or Akt suggested as downstream mediators of TBK1 action (14, 15, 16, 17, 42, 43, 44, 45, 46). The gene discussed is TBK1; the disease is neoplasm.