Beyond its well-known role in innate immunity, TBK1 has been implicated in oncogenesis and metabolic disorders linked to obesity such as type II diabetes, similar to mTOR and Akt (14, 15, 16, 17, 28, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54). The gene discussed is TBK1; the disease is obesity disorder.