Focusing more on therapeutic approaches in relation with neuroinflammation, Martin et al. published various papers using TSPO as reference for neuroinflammation imaging in which they examine the involvement of α4β2 nicotinic acetylcholine receptor (nAChR) [96], the cystine-glutamate antiporter system xc- [97], toll-like receptor 4 (TLR4) [98] and the adenosine A1 receptors (A1AR) [99] in the regulation of neuroinflammation after stroke. This evidence concerns the gene TLR4 and Stroke.