While multi‐ancestral adenomas and adenocarcinomas have been identified in both sporadic and familial cases of colorectal cancer in humans, previous studies did not address the fate of ancestral clones that carry mutations in key tumor driver genes such as KRAS, PIK3CA encoding PI3K, or TP53, which are commonly mutated in colorectal cancers.15, 35, 36. Here, PIK3CA is linked to adenoma.