However, with DSG2, SOX4 and SOX2 all previously implicated in tumour angiogenesis [12, 14, 32, 33] factors other than VEGFA may be contributing to the microvascular density in MM, and while we had insufficient patient trephine biopsies to compare DSG2 expression with microvascular density, this will be investigated in future studies. Here, SOX4 is linked to neoplasm.