In the present study, we only examined male mice in order to avoid the strong effects of sex hormones or the estrus cycle; however, it is likely that female AppNL−F/NL−F mice may exhibit a much higher susceptibility to HFD; thus, the AD pathology would be more strongly exacerbated because sex‐dependent TTR modulation of brain Aβ levels or adult neurogenesis has been reported (Oliveira et al., 2011; Vancamp et al., 2019). This evidence concerns the gene TTR and Alzheimer disease.