APP and Alzheimer disease: Because in comparison with AppNL/NL mice, AppNL−F/NL−F mice have an additional Iberian “F” mutation in the App gene, which is known to increase Aβ42 production by altering the γ secretase processing of the C‐terminal end of Aβ (Saito et al., 2014), our results clearly indicate that the Iberian “F” mutation is essential to make AppNL−F/NL−F mice susceptible to T2DM as a risk factor for the pathogenesis of AD.