HIF1 α and HIF2 α affect tumor progression by directly regulating distinctive and allocated target genes such as SCGB3A1 in NSCLC,22 and ADRP, ADAM1, BNIP3, CCND1, GLUT1, IL‐6, TGF α, and VEGF in renal cell carcinoma.4, 23, 24, 25, 26. The gene discussed is IL6; the disease is non-small cell lung carcinoma.