HIF1 α and HIF2 α affect tumor progression by directly regulating distinctive and allocated target genes such as SCGB3A1 in NSCLC,22 and ADRP, ADAM1, BNIP3, CCND1, GLUT1, IL‐6, TGF α, and VEGF in renal cell carcinoma.4, 23, 24, 25, 26. This evidence concerns the gene BNIP3 and renal cell carcinoma.