HIF1 α and HIF2 α affect tumor progression by directly regulating distinctive and allocated target genes such as SCGB3A1 in NSCLC,22 and ADRP, ADAM1, BNIP3, CCND1, GLUT1, IL‐6, TGF α, and VEGF in renal cell carcinoma.4, 23, 24, 25, 26. The gene discussed is BNIP3; the disease is hereditary clear cell renal cell carcinoma.