Another study characterising MUTYH variants in Ashkenazi Jews compared to individuals of other ancestry found that, although monoallelic MUTYH mutations were rare, they did find that, when present, they were significantly associated with a personal history of CRC regardless of ancestry (OR 1.78; 95% CI 1.21–2.49; P < 0.01) [18]. The gene discussed is MUTYH; the disease is colorectal carcinoma.