PTPA and lung cancer: For example, COG112, anapolipoprotein E-mimetic peptide interacting with SET, inhibited the motility of various cancer cells33; FTY720, a synthetic sphingosine analogue, binds to SET, leading to PP2A activation and anti-tumour activity in lung cancer and colorectal cancer24,36; and OP449 (COG449), a synthetic peptide, directly binds to SET and/or interferes with its PP2A-inhibition function37.