Immunohistochemistry confirmed the reduction in SET protein levels in tumours developed in the siSET-treated group: H-scores of tumours were 187.5 ± 52.0 for non-treated group, 198.3 ± 45.8 for siControl, and 66.7 ± 39.8 for siSET group, P < 0.05 (Fig. 3c). Here, SET is linked to neoplasm.