Delivery of an hnRNPLL-specific shRNA into A8i-A cells or transfection of hnRNPLL cDNA into A8i cells repressed or enhanced 3D culture growth, tumor growth, and ECM1a, pAKT, pFAK, pPaxillin and pRac expression, respectively (Fig. 5j–o). The gene discussed is HNRNPLL; the disease is neoplasm.