Whether our findings of the opposite tumorigenic functions between ECM1a and ECM1b, cytoskeletal phosphorylation induced by the ECM1a-integrin αXβ2 interaction, hnRNPLL-regulated ECM1a mRNA splicing, and ABCG1-mediated cytoskeletal phosphorylation and cancer stemness apply to different cancer cell types warrants comprehensive investigation. Here, ABCG1 is linked to cancer.