Intriguingly, tumor-suppressive effect elicited by JAB1 knockdown is >p38MAPK inhibitor SB203580 (Figs. 7 and 8), indicating that JAB1 regulation of TNBC tumorigenesis may be multi-pronged and one prong being the p38MAPK/MK2 signaling pathway. The gene discussed is COPS5; the disease is neoplasm.