MTAP and hyperinsulinemic hypoglycemia, familial, 4: However, our study does not rule out other factors that could influence MTA accumulation in MTAP-deleted cells, i.e., extreme cysteine deficiency shown by Sanderson et al.11 (though physiological media Plasmax still yielded MTA secretion in MTAP-deleted glioma cells, Supplementary Fig. 10).