LAIR1 and malaria: The extensive sequence diversity of the LAIR1-binding surface of RIFIN—even among those RIFINS that we demonstrated to be positive for LAIR1 binding by co-immunoprecipitation—along with the sequence conservation of LAIR1s from hosts infected by malaria (Fig. 2b) highlights the complex polymorphic interactions that malaria parasites make with host factors to enhance their survival.