WDR4 and hepatocellular carcinoma: To investigate the roles of WDR4 in HCC progression, we first evaluated the mRNA and protein levels of WDR4 in four HCC cell lines (Hep-3B, Hep-G2, HCC-LM3, and Huh-7) and observed that they were upregulated compared to those observed in hepatocytes (L02 cells; Fig. 1D).