WDR4 and hepatocellular carcinoma: Then, we constructed sorafenib-resistant Huh-7R, HCC-LM3R, and Li-7R cells and observed that WDR4 overexpression significantly increased the IC50 value of sorafenib in Huh-7R and HCC-LM3R cells, while WDR4 knockdown significantly decreased the IC50 value in Li-7R cells (Figs. 3D and S1J, S1K).