In order to validate whether the results obtained in our CRISPR/Cas9-generated models could resemble the actual biology of BIRC3-deleted del(11q) CLL patients, we tested the DNA-binding activity of non-canonical NF-κB transcription factors in a cohort of 22 CLL cases (n = 11 BIRC3WT; n = 11 BIRC3-deleted through del(11q) or mutation) (Supplementary Table S2) in the absence or presence of stromal + CpG + IL-2 stimulation. The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.