BIRC3 and B-cell chronic lymphocytic leukemia: sgRNAs targeting chromosomal bands 11q22.1 and 11q23.3 were introduced in Cas9-expressing HG3 cells, generating an isogenic HG3 CLL cell line harboring a ∼17 Mb monoallelic del(11q) (HG3-del(11q)) encompassing BIRC3 gene among others [27].