BIRC3 and B-cell chronic lymphocytic leukemia: Indeed, further evidence of hyperactive non-canonical signaling was found in B-lymphocytes from mice lacking cIap1/cIap2 (Birc2/Birc3) [37] and in B-cells treated with BIRC2/BIRC3 inhibitors [21], as well as in our isogenic del(11q) CLL cell lines (Fig. 2).