Previous studies revealed that the E2F family of transcription factor 2 (E2F2) plays a crucial role in the development and progression of various cancers, such as ovarian cancer [51], lung cancer [52], and hepatocellular carcinoma [53], promoting cell-cycle progression, stemness, metastasis, and chemoresistance [54]. Here, HNF1B is linked to hepatocellular carcinoma.