More importantly, cell lines with mere PSMC2 knockdown (shPSMC2+Vector), mere PLAU overexpression (PLAU + shCtrl), or simultaneous PSMC2 knockdown and PLAU overexpression (shPSMC2+PLAU) were constructed for further demonstrating the synergistic effects of PSMC2 and PLAU on breast cancer development (Fig. S8). The gene discussed is PLAU; the disease is breast carcinoma.