Taurodontism was also recognized in the Torg-Winchester syndrome [OMIM 259600] in which the wrists and ankles are affected and there is progressive dissolution of the carpals and tarsals.29 Two separate mutations in the MMP2 gene result in complete loss of matrix metalloproteinase activity.30,31 This disorder probably represents a continuous clinical spectrum which results from intragenic heterogeneity in the MMP2 gene and the eponym “Torg-Winchester syndrome” is now widely accepted. Here, MMP2 is linked to taurodontism.