The DEmiRNAs identified with the meta-analysis involved in Aβ metabolism, including APP expression, Aβ-production enzyme regulation, and Aβ clearance, tau protein phosphorylation, and also contribute to neuronal function during AD progression, including pathogenic neuroinflammation, apoptosis, mitochondrial oxygen chain activity, and neuronal microtubule maintenance. Here, MAPT is linked to Alzheimer disease.