Additionally, hypoxic tumor-derived exosomal lncRNA urothelial cancer-associated 1 (UCA1) was shown to promote angiogenesis via miRNA-96-5p/AMOTL2 (angiomotin-like 2) in PaCa [69]. This evidence concerns the gene AMOTL2 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.