Activation of these innate immune cells could kill some of the cancer cells that would release tumor antigens, which then activate tumor antigen-specific T cell responses systemically in peripheral blood, spleen, tumor-draining lymph nodes and within tumor tissues, promotes NK cell and T cell infiltration and cytokine secretion (such as granzyme B) that could kill cancer cells [19]. The gene discussed is GZMB; the disease is neoplasm.