TGFB1 and neoplasm: Besides expressing more checkpoint molecules on effector T cells, TME is infiltrated with various immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) as well as their effector molecules, such as IL-10 and TGF-β, to form a strong immune suppressive network or TME [11–13, 18] within solid tumors.