Malignant solid tumor also secretes signal molecules to recruit immature immune cells and other cells to enter the tumor, then educate, or reprogram them to become immune suppressor cells (such as MDSC, Treg, TAM and CAF) that could secrete immunosuppressive molecules (such as IL-10 and TGF-β), therefore forming the immunosuppressive microenvironment [11–13, 18]. Here, TGFB1 is linked to neoplasm.