Approximately 15% of CRC cases are MSI-High (MSI-H); 3% of which include hereditary polyposis colorectal cancer (HNPCC) or Lynch syndrome and sporadic MSI-H CRC, typically caused by somatic methylation of the MLH1 gene promoter, making up the remaining 12% of cases [2, 3]. Here, MLH1 is linked to colorectal carcinoma.