As it was the goal of this study to evaluate the effects of the delivery of oxygen and its independent parameters (Hb, arterial SaO2 and CI) on the development of II we tried to attenuate these factors by identifying and adjusting for anamenstic proxies and conditions for a higher risk of II like diabetes mellitus, peripheral vascular disease, chronic heart failure, coronary heart and pulmonary diseases and used them for the stratification of the Cox model. The gene discussed is GSTM1; the disease is vascular disorder.