ICAM1 and COVID-19: Pancreatic and islet expression of intercellular adhesion molecule 1 (ICAM1), a marker of endothelial dysfunction and inflammation (25), was increased in individuals with COVID-19 compared with controls, suggesting the presence of endotheliitis of the entire pancreatic vasculature (Figure 7, E and F) and the islet microvasculature (Figure 7G).