TRAF6 and infectious otitis media: For example, we previously reported that MST4 targets the E3 ligase TRAF6 to limit innate inflammatory responses.[43] Besides, our previous study observed that MST4 phosphorylates YAP and regulates Hippo/YAP signaling to suppress gastric tumorigenesis.[44] Here, in the intestinal crypts of mice, we did not observe an apparent effect of MST4 on YAP under physiological condition; but did observe a positive role of MST4 on YAP protein levels during AOM/DSS‐induced tumorigenesis (data not shown).