This double-pathway activation, concurrent with Hif-1α buildup, is also observed in neoplasia induced by losses of lethal (2) giant larvae [l(2)gl, hereafter referred to as lgl] and ribosomal protein L27A (RpL27A) (Grifoni et al., 2015), suggesting that the pathway activation in Pvr tumors may be shared among tumors of different genetic makeups. The gene discussed is RPL27A; the disease is neoplasm.