Interestingly, the increased expression of Hif1a suggests that the instability and/or infection results in a more hypoxic environment, although this did not translate to significant differences in hypoxia-inducible factor (Hif)-1α regulated genes such as Vegfa, which could suggest an inadequate adaptation to hypoxia as suggested by Hoff et al. (Hoff et al., 2011). This evidence concerns the gene VEGFA and infection.