Also, data from the population-based Saarland Cancer Registry, including 9359 female patients with primary invasive breast cancer between 1999 and 2009, demonstrate that the risk for recurrence (both locoregional and systemic) is particularly increased if tumours are locally or regionally advanced (T3/4 N+), of high grade or classified as subtype HER 2-positive without hormone receptor expression or triple negative. Here, NR4A1 is linked to invasive breast carcinoma.