LMNA and Emery-Dreifuss muscular dystrophy: ,37,38 The most common variant our cohort, an Arg249Trp substitution, was primarily associated with congenital and early onset laminopathies and has not been associated with later-onset clinical subttypes (EDMD or LGMD1B) (www.umd.be/LMNA/, GB and RBY personal communication).